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Matchups for Oct. 7, 2022 include:
- ADM vs. Harlan (A11)
- Ankeny at Des Moines North (A13)
- I-35 vs. Van Meter (A14)
- Mount Ayr vs. Earlham (B5)
- Cedar Rapids Washington vs. Newton (B8)
- Dowling Catholic vs. Ames (C4)
- Waukee NW vs. Centennial (C5)
- Ballard vs. North Polk (C6)
- Cedar Rapids Prairie at Southeast Polk (D3)
- Carlisle vs. Indianola (D4)
- Des Moines Lincoln vs. West Des Moines Valley (D5)
- Marshalltown vs. Des Moines Roosevelt (E4)
- Johnston vs. Sioux City North (E5)